Some of the interesting highlights are the relationship between theory and data in the adjudication of explanatory hypotheses, scientific and otherwise. More importantly, I think, is the realization, which he makes explicit through some awesome examples, of the unavoidable cognitive biases to which we are all subject when we try to figure something out: we focus on certain things while ignoring others in order to get the results we intuitively think are correct.
I know Daniel Dennett greatly respects Wilson as a well-established biologist, but he thinks the answer to the question of the evolution of religion lies in memetic theory and not in group selection theory (you can watch Dennett's fascinating presentation arguing his point in this previous entry). I wonder what Wilson thinks of Dennett's memetic theory of religion... maybe I should ask him, right?
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